# Lymphodepletion With Low Dose Total Body Irradiation Before Standard of Care Tisagenlecleucel for the Treatment of Relapsed and Recurrent Large B-cell Lymphoma

> **NCT07676877** · PHASE1 · RECRUITING · sponsor: **Nathan Denlinger** · enrollment: 18 (estimated)

## Conditions studied

- Recurrent Diffuse Large B-Cell Lymphoma
- Refractory Diffuse Large B-Cell Lymphoma

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine
- **PROCEDURE:** Leukapheresis
- **PROCEDURE:** Positron Emission Tomography
- **BIOLOGICAL:** Tisagenlecleucel
- **RADIATION:** Total-Body Irradiation

## Key facts

- **NCT ID:** NCT07676877
- **Lead sponsor:** Nathan Denlinger
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-12-01
- **Primary completion:** 2027-12-31
- **Final completion:** 2027-12-31
- **Target enrollment:** 18 (ESTIMATED)
- **Last updated:** 2026-10-09

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07676877

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07676877, "Lymphodepletion With Low Dose Total Body Irradiation Before Standard of Care Tisagenlecleucel for the Treatment of Relapsed and Recurrent Large B-cell Lymphoma". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07676877. Licensed CC0.

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