# A First-in-human Study to Assess the Initial Safety, Tolerability, and Effectiveness of the ONSS Bilateral Occipital Nerve Field Stimulation System for the Prophylactic Treatment of Chronic Cluster Headache in Difficult-to-treat Subjects.

> **NCT07677137** · NA · RECRUITING · sponsor: **Man and Science, SA** · enrollment: 10 (estimated)

## Conditions studied

- Chronic Cluster Headache

## Interventions

- **DEVICE:** Occipital Nerve Stimulation System

## Key facts

- **NCT ID:** NCT07677137
- **Lead sponsor:** Man and Science, SA
- **Sponsor class:** INDUSTRY
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-05-18
- **Primary completion:** 2027-07
- **Final completion:** 2027-07
- **Target enrollment:** 10 (ESTIMATED)
- **Last updated:** 2026-08-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07677137

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07677137, "A First-in-human Study to Assess the Initial Safety, Tolerability, and Effectiveness of the ONSS Bilateral Occipital Nerve Field Stimulation System for the Prophylactic Treatment of Chronic Cluster Headache in Difficult-to-treat Subjects.". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07677137. Licensed CC0.

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