# Adjunctive Oral Probiotics in Endodontic Retreatment: Effects on Postoperative Pain and RANKL/OPG Levels

> **NCT07683520** · PHASE4 · COMPLETED · sponsor: **Ain Shams University** · enrollment: 72 (actual)

## Conditions studied

- Chronic Apical Periodontitis

## Interventions

- **DIETARY_SUPPLEMENT:** Linex Adult®
- **DRUG:** Ca(OH)2 as intracanal medicament
- **OTHER:** Placebo
- **DRUG:** propolis intracanal medication
- **OTHER:** Empty canal

## Key facts

- **NCT ID:** NCT07683520
- **Lead sponsor:** Ain Shams University
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2025-10-04
- **Primary completion:** 2026-06-04
- **Final completion:** 2026-06-20
- **Target enrollment:** 72 (ACTUAL)
- **Last updated:** 2026-07-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07683520

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07683520, "Adjunctive Oral Probiotics in Endodontic Retreatment: Effects on Postoperative Pain and RANKL/OPG Levels". Retrieved via MORVS 2026-10-21 from https://api.morvs.ai/clinical/NCT07683520. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*