# CBP-0276 to Reduce Opioid Use in Adults Undergoing Major Orthopedic Surgery

> **NCT07687966** · PHASE2 · RECRUITING · sponsor: **Clarent Biopharma, Inc.** · enrollment: 80 (estimated)

## Conditions studied

- Hip or Knee Replacement

## Interventions

- **DRUG:** CBP-0276
- **DRUG:** Placebo for CBP-0276

## Key facts

- **NCT ID:** NCT07687966
- **Lead sponsor:** Clarent Biopharma, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-05-08
- **Primary completion:** 2026-06-30
- **Final completion:** 2026-09-30
- **Target enrollment:** 80 (ESTIMATED)
- **Last updated:** 2026-07-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07687966

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07687966, "CBP-0276 to Reduce Opioid Use in Adults Undergoing Major Orthopedic Surgery". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07687966. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*