Belinostat in Combination With Azacitidine or Pralatrexate for the Treatment of Relapse or Refractory T-cell Lymphoma

Conditions

• Recurrent Anaplastic Large Cell Lymphoma
• Recurrent Enteropathy-Associated T-Cell Lymphoma
• Recurrent Follicular Helper T-Cell Lymphoma
• Recurrent Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type
• Recurrent Follicular Helper T-Cell Lymphoma, Follicular-Type
• Recurrent Follicular Helper T-Cell Lymphoma, Not Otherwise Specified
• Recurrent Hepatosplenic T-Cell Lymphoma
• Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
• Recurrent Monomorphic Epitheliotropic Intestinal T-cell Lymphoma
• Recurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified
• Recurrent Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma
• Recurrent Primary Cutaneous Gamma-Delta T-Cell Lymphoma
• Recurrent Subcutaneous Panniculitis-Like T-Cell Lymphoma
• Refractory Anaplastic Large Cell Lymphoma
• Refractory Enteropathy-Associated T-Cell Lymphoma
• Refractory Follicular Helper T-Cell Lymphoma
• Refractory Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type
• Refractory Follicular Helper T-Cell Lymphoma, Follicular-Type
• Refractory Follicular Helper T-Cell Lymphoma, Not Otherwise Specified
• Refractory Hepatosplenic T-Cell Lymphoma
• Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
• Refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma
• Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified
• Refractory Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma
• Refractory Primary Cutaneous Gamma-Delta T-Cell Lymphoma
• Refractory Subcutaneous Panniculitis-Like T-Cell Lymphoma

Interventions

• DRUG: Azacitidine
• DRUG: Belinostat
• PROCEDURE: Biospecimen Collection
• PROCEDURE: Computed Tomography
• PROCEDURE: FDG-Positron Emission Tomography
• OTHER: Fludeoxyglucose F-18
• PROCEDURE: Positron Emission Tomography
• DRUG: Pralatrexate
• OTHER: Questionnaire Administration

Sponsor

City of Hope Medical Center

Collaborators

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