# Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in Men

> **NCT07691827** · — · RECRUITING · sponsor: **The Third Affiliated Hospital of Guangzhou Medical University** · enrollment: 1200 (estimated)

## Conditions studied

- Azoospermia, Nonobstructive
- Cryptozoospermia

## Interventions

_None listed._

## Key facts

- **NCT ID:** NCT07691827
- **Lead sponsor:** The Third Affiliated Hospital of Guangzhou Medical University
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2021-04-01
- **Primary completion:** 2027-04-01
- **Final completion:** 2027-06-01
- **Target enrollment:** 1200 (ESTIMATED)
- **Last updated:** 2026-07-09


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07691827

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07691827, "Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in Men". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07691827. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*