# Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder

> **NCT07703722** · PHASE3 · RECRUITING · sponsor: **Khyber Medical University Peshawar** · enrollment: 60 (estimated)

## Conditions studied

- Major Depressive Disorder
- Post-Traumatic Stress Disorder (PTSD)

## Interventions

- **DRUG:** Psilocybin
- **BEHAVIORAL:** Structured Integrated Reframing Therapy (SIRT)
- **DRUG:** Selective Serotonin Reuptake Inhibitor (SSRI)

## Key facts

- **NCT ID:** NCT07703722
- **Lead sponsor:** Khyber Medical University Peshawar
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-04-01
- **Primary completion:** 2027-10-22
- **Final completion:** 2027-11-22
- **Target enrollment:** 60 (ESTIMATED)
- **Last updated:** 2026-07-14

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07703722

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07703722, "Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07703722. Licensed CC0.

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