# Epcoritamab and Pola-R-mini-CHP for the Treatment of Diffuse Large B Cell Lymphoma in Elderly or Unfit Patients

> **NCT07714421** · PHASE1 · NOT_YET_RECRUITING · sponsor: **Jonsson Comprehensive Cancer Center** · enrollment: 20 (estimated)

## Conditions studied

- Diffuse Large B-Cell Lymphoma
- Grade 3b Follicular Lymphoma
- High Grade B-Cell Lymphoma
- Primary Mediastinal Large B-Cell Lymphoma
- Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **DRUG:** Doxorubicin
- **BIOLOGICAL:** Epcoritamab
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Polatuzumab Vedotin
- **PROCEDURE:** Positron Emission Tomography
- **DRUG:** Prednisone
- **BIOLOGICAL:** Rituximab

## Key facts

- **NCT ID:** NCT07714421
- **Lead sponsor:** Jonsson Comprehensive Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-12-08
- **Primary completion:** 2030-10-08
- **Final completion:** 2031-10-08
- **Target enrollment:** 20 (ESTIMATED)
- **Last updated:** 2026-07-20

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07714421

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07714421, "Epcoritamab and Pola-R-mini-CHP for the Treatment of Diffuse Large B Cell Lymphoma in Elderly or Unfit Patients". Retrieved via MORVS 2026-10-21 from https://api.morvs.ai/clinical/NCT07714421. Licensed CC0.

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