# Radiotherapy Dose Escalation for Non-operative Management of Unresectable Locally Recurrent Rectal Cancer (STEP-UP)

> **NCT07721181** · NA · RECRUITING · sponsor: **Heike M.U. Peulen** · enrollment: 30 (estimated)

## Conditions studied

- Locally Recurrent Rectal Cancer

## Interventions

- **RADIATION:** SBRT
- **RADIATION:** Hyperfractionated chemo-reirradiation
- **RADIATION:** Full-course chemoradiotherapy

## Key facts

- **NCT ID:** NCT07721181
- **Lead sponsor:** Heike M.U. Peulen
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-09-01
- **Primary completion:** 2029-12-31
- **Final completion:** 2031-12-31
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2026-07-22

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07721181

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07721181, "Radiotherapy Dose Escalation for Non-operative Management of Unresectable Locally Recurrent Rectal Cancer (STEP-UP)". Retrieved via MORVS 2026-10-21 from https://api.morvs.ai/clinical/NCT07721181. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*