# Oral GnRH Antagonist (Linzagolix) Versus Injectable GnRH Antagonist in Controlled Ovarian Stimulation for In Vitro Fertilization: A Randomized Controlled Non-Inferiority Trial With a Concurrent Comparator Cohort Undergoing Progestin-Primed Ovarian Stimulation (PPOS)

> **NCT07732348** · NA · NOT_YET_RECRUITING · sponsor: **Centro A.M.B.R.A. (Associazione Medici e Biologi per la Riproduzione Assistita)** · enrollment: 120 (estimated)

## Conditions studied

- Infertility, Female
- Ovulation Induction

## Interventions

- **DRUG:** Ganirelix ; Cetrorelix
- **DRUG:** Medroxyprogesterone Acetate ; Micronized Progesterone
- **DRUG:** Linzagolix

## Key facts

- **NCT ID:** NCT07732348
- **Lead sponsor:** Centro A.M.B.R.A. (Associazione Medici e Biologi per la Riproduzione Assistita)
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-09
- **Primary completion:** 2026-12
- **Final completion:** 2026-12
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2026-09-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07732348

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07732348, "Oral GnRH Antagonist (Linzagolix) Versus Injectable GnRH Antagonist in Controlled Ovarian Stimulation for In Vitro Fertilization: A Randomized Controlled Non-Inferiority Trial With a Concurrent Comparator Cohort Undergoing Progestin-Primed Ovarian Stimulation (PPOS)". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07732348. Licensed CC0.

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