# Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.

> **NCT07736352** · NA · NOT_YET_RECRUITING · sponsor: **China-Japan Friendship Hospital** · enrollment: 100 (estimated)

## Conditions studied

- Knee Osteoarthritis
- Replacement, Knee
- Elective Surgical Patients
- ASA Class I/II Patients

## Interventions

- **DRUG:** Propofol + Remifentanil +Midazolam
- **DRUG:** Propofol + Remifentanil + Dexmedetomidine
- **DRUG:** Propofol + Remifentanil + Esketamine
- **DRUG:** Propofol + Remifentanil

## Key facts

- **NCT ID:** NCT07736352
- **Lead sponsor:** China-Japan Friendship Hospital
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-08-01
- **Primary completion:** 2027-01-31
- **Final completion:** 2027-07-31
- **Target enrollment:** 100 (ESTIMATED)
- **Last updated:** 2026-07-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07736352

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07736352, "Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07736352. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*