# ctDNA-driven Adaptive Proton Craniospinal Irradiation in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis After Resistance to Third-Generation TKIs in the Consolidation Phase

> **NCT07751536** · NA · RECRUITING · sponsor: **Shuanghu Yuan** · enrollment: 84 (estimated)

## Conditions studied

- Leptomeningeal Metastasis From Lung Cancer

## Interventions

- **RADIATION:** proton craniospinal irradiation
- **DRUG:** Intrathecal pemetrexed

## Key facts

- **NCT ID:** NCT07751536
- **Lead sponsor:** Shuanghu Yuan
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2026-08-05
- **Primary completion:** 2028-07-31
- **Final completion:** 2028-07-31
- **Target enrollment:** 84 (ESTIMATED)
- **Last updated:** 2026-08-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07751536

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07751536, "ctDNA-driven Adaptive Proton Craniospinal Irradiation in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis After Resistance to Third-Generation TKIs in the Consolidation Phase". Retrieved via MORVS 2026-10-20 from https://api.morvs.ai/clinical/NCT07751536. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*