# Translation analysis of a novel intervention for diet-induced obesity

> **NIH NIH R21** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $232,500

## Abstract

Project Summary
 Advancing age is associated with an increased risk of type 2 diabetes, which is exacerbated by the high
prevalence of obesity in the aged. These disorders are risk factors for age-related diseases associated with
significant morbidity and mortality, including cancer, cardiovascular disease, and Alzheimer’s disease. New
approaches to maintain glucose homeostasis in the aged are therefore urgently needed. The objective of the
proposed study is to test a reduced branched-chain amino acid diet, recently shown in mice to reverse diet
induced obesity and insulin resistance, in a small nonhuman primate, the common marmoset. We will also gain
insight into the molecular mechanisms induced by reduced dietary branched-chain amino acids through
comparative metabolomic and proteomic analysis of blood and skeletal muscle samples from marmosets and
from young and aged mice. These studies are urgently needed to understand if manipulation of specific dietary
amino acids is a translatable intervention to promote metabolic health and increase healthspan.

## Key facts

- **NIH application ID:** 10023250
- **Project number:** 5R21AG061635-02
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** RICKI J COLMAN
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $232,500
- **Award type:** 5
- **Project period:** 2019-09-30 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10023250

## Citation

> US National Institutes of Health, RePORTER application 10023250, Translation analysis of a novel intervention for diet-induced obesity (5R21AG061635-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/10023250. Licensed CC0.

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