# CE24-012 - The Impact of Recreational Cannabis Legalization on Substance Use Outcomes

> **NIH ALLCDC R01** · NORTHWESTERN UNIVERSITY · 2024 · $348,719

## Abstract

PROJECT ABSTRACT
This project will rigorously assess the impact of recreational cannabis legalization on opioid use and overdoses
across the United States. With nearly half of the U.S. population living in states where recreational cannabis is
legal, and ongoing policy shifts influencing its availability, this research is both timely and critical. The study will
have two specific aims: first, to measure the effects of recreational cannabis legalization on substance use for
self-management of pain, utilizing a nationally representative survey with detailed drug-use data; second, the
project will quantify the impact of these policies on opioid morbidity and mortality, combining survey data with
nationwide overdose data to assess changes in non-fatal and fatal overdoses. For each aim, the team will test
for differences in the impact of cannabis legalization across 1) policy implementation characteristics and 2)
individual sociodemographic determinants of health. The research approach will employ a rigorous, quasi-
experimental statistical methodology, led by a multidisciplinary team of experts in substance use policy
research, addiction medicine, and statistical methods. The outcome of this study will provide crucial evidence-
based information to inform policymakers and public health officials in crafting effective interventions that
address the complex relationship between cannabis policy, health disparities, and substance use outcomes.

## Key facts

- **NIH application ID:** 10993984
- **Project number:** 1R01CE003675-01
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Lindsay Allen
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** ALLCDC
- **Fiscal year:** 2024
- **Award amount:** $348,719
- **Award type:** 1
- **Project period:** 2024-09-30 → 2027-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10993984

## Citation

> US National Institutes of Health, RePORTER application 10993984, CE24-012 - The Impact of Recreational Cannabis Legalization on Substance Use Outcomes (1R01CE003675-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/10993984. Licensed CC0.

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