Identification of Novel Syk/Raf-1 Mediated CLR Ligands as Vaccine Adjuvants

Abstract

The contractor proposes to screen libraries of synthetic putative CLR agonists that induce Th17 or Th17/Th1 immunity as adjuvants for bacterial and fungal pathogens. Age-specific immune phenotyping will be conducted in mice and with human cells and optimized, formulated lead candidates will be tested in models of Mtb and coccidioidomycosis.

Key facts

NIH application ID

11203002

Project number

75N93024C00024-0-9999-1

Recipient

UNIVERSITY OF MONTANA

Principal Investigator

JAY EVANS

Activity code

N01

Funding institute

NIH

Fiscal year

2024

Award amount

$1,637,656

Award type

—

Project period

2024-09-30 → 2029-09-29