# NEURAL AND HORMONAL INTERACTIONS DURING PUBERTY

> **NIH NIH K04** · MICHIGAN STATE UNIVERSITY · 1994 · $64,654

## Abstract

The research project investigates the cellular basis for developmental
shifts in responsiveness to endocrine and behavioral effects of
testosterone during puberty in males.  The hypotheses to be tested include:
1) whether changes in responsiveness to testosterone are mediated by
quantitative changes in nuclear retention of steroid in target neurons or
differential intraneuronal steroid metabolism; 2) whether the site of
action of testosterone negative feedback on gonadotropin-releasing hormone
secretion is at the level of neuronal cell bodies or terminals; and 3)
whether endocrine and behavioral effects of testosterone are mediated by
separate populations of steroid receptive neurons.  The experiments employ
steroid autoradiography, tract-tracing, immunocytochemistry, and
combinations of these techniques.

## Key facts

- **NIH application ID:** 2194418
- **Project number:** 5K04HD000950-04
- **Recipient organization:** MICHIGAN STATE UNIVERSITY
- **SAM.gov UEI:** R28EKN92ZTZ9
- **Principal Investigator:** CHERYL L. SISK
- **Activity code:** K04 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $64,654
- **Award type:** 5
- **Project period:** 1991-04-01 → 1996-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194418

## Citation

> US National Institutes of Health, RePORTER application 2194418, NEURAL AND HORMONAL INTERACTIONS DURING PUBERTY (5K04HD000950-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194418. Licensed CC0.

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