# ROLE OF INTERLEUKIN-6 IN PRETERM LABOR

> **NIH NIH K08** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 1994 · $82,620

## Abstract

This research project will be to investigate the role of interleukin-6 in
the pathophysiology of preterm labor.  The hypotheses to be tested include:
(1) IL-6 is produced by gestational tissues in response to infection and
that IL-6 will stimulate prostaglandin production by decidua and amnion;
(2) the regulation of IL-t production is mediated by other inflammatory
cytokines, effectors of cell signal transduction, and steroid hormones; and
(3) determination of amniotic fluid and/or serum IL-6 is a useful
biochemical marker of infection-induced preterm labor.  Four groups of
patients will be studied:  infection-induced preterm labor, idiopathic
preterm labor, term labor, and term at cesarean section (not in labor).
Cultured trophoblast, decidua, chorion and amnion will be used for these
studies.  Basal IL-6 production from these tissues will be determined using
IL-6 ELISA and bioassay.  The regulation of IL-6 production from selected
tissues by other inflammatory cytokines, cell signal transduction agonists
and antagonists, and steroid hormones will be studied.  The sensitivity and
specificity of amniotic fluid and serum IL-6 determination in predicting
infection-induced preterm labor will also be determined.

## Key facts

- **NIH application ID:** 2194428
- **Project number:** 5K08HD000964-04
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **SAM.gov UEI:** LL8GLEVH6MG3
- **Principal Investigator:** DONALD J DUDLEY
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $82,620
- **Award type:** 5
- **Project period:** 1991-08-01 → 1996-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194428

## Citation

> US National Institutes of Health, RePORTER application 2194428, ROLE OF INTERLEUKIN-6 IN PRETERM LABOR (5K08HD000964-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194428. Licensed CC0.

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