# GONADOTROPIN RECEPTORS

> **NIH NIH K04** · UNIVERSITY OF IOWA · 1994 · $66,980

## Abstract

My career goals have been to attain a tenured position in an environment
that will foster the growth of my research program.  It is clear that the
Department of Physiology and Biophysics at The University of Iowa offers
such an environment.  My research has focused upon the LH/CG and FSH
receptors, whose functions play a pivotal role in reproductive physiology.
We hope to learn in progressively greater detail the structure of these
receptors and the mechanisms underlying their mechanism of action and
regulation.  These studies have been greatly advanced by our recent ability
to clone the cDNA's for the rat LH/CG and FSH receptors.  Thus, we now have
the experimental tools to address important physiological questions
concerning the biology of these receptors.  Specifically, the overall
specific aims that I have set for my laboratory for the next five years are
to (1) examine the induction and/or regulation of ovarian and testicular
LH/CG and FSH receptors at the levels of transcription and translation; (2)
clone, express, and characterize the 5' flanking regions of the LH/CG and
FSH receptor genes in order to study the cell-specific and
hormonally-regulated expression of these receptors; and (3) map functional
domains of the LH/CG and FSH receptors by constructing and characterizing
mutant and chimeric forms of the receptors.

The information gained from these studies will significantly aid in our
understanding of the regulation of testicular and ovarian function, as well
as human fertility and infertility.  They will also contribute to our
understanding of the mechanisms by which G protein-coupled receptors
transmit extracellular events into intracellular signals.

Salary support is being requested in order to reduce the amount of time I
am obligated to spend in teaching and committee functions, allowing me to
devote more of my time (at least 80%) to the laboratory.  This will be
critical for sustaining the momentum of my ongoing research, and thus
further help establish myself as an independent investigator.

## Key facts

- **NIH application ID:** 2194436
- **Project number:** 5K04HD000968-03
- **Recipient organization:** UNIVERSITY OF IOWA
- **SAM.gov UEI:** Z1H9VJS8NG16
- **Principal Investigator:** DEBORAH SEGALOFF
- **Activity code:** K04 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $66,980
- **Award type:** 5
- **Project period:** 1992-04-01 → 1997-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194436

## Citation

> US National Institutes of Health, RePORTER application 2194436, GONADOTROPIN RECEPTORS (5K04HD000968-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194436. Licensed CC0.

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