# HUMAN FSH-RECEPTOR BINDING INHIBITORS

> **NIH NIH K08** · ALBANY MEDICAL COLLEGE · 1994 · $75,600

## Abstract

A. The Candidate

Dr. Daniel W. Lee obtained the M.D. degree in 1982 and is Board
Certified in Internal Medicine and also in the subspecialty of
Endocrinology and Metabolism.  He is currently the recipient of a
National Research Service Award (NIH) for the period 11/01/88 -
10/31/91.  The present proposal is for a Clinical Investigator
Award (5 years) to support his further development as an
independent clinical investigator.

B. The Research

The principle goal of this project is to purify and study a
previously identified large molecular weight FSH-receptor binding
inhibitor (FSH-BI) from human follicular fluid (hFF) which may be
involved in the autocrine or paracrine regulation of follicular
maturation.  The specific goals of the project are to: 1) purify
human FSHBI from hFF, 2) biologically characterize hFSH-BI by
studying its agonist/antagonist properties as well as its effects
on various systems known to respond to FSH, 3) develop an assay
for measurement of hFSH-BI in hFF, 4) determine its cell of
origin, 5) clone and sequence FSH-BI and 6) study FSH-BI
synthesis and expression in follicles of varying maturity.

C. The Environment

Dr. Leo E. Reichert, Jr., Professor of Biochemistry and Sponsor,
has had a long standing interest in gonadotropin hormone and
receptor chemistry and mechanism of action and in factors that
affect the hormone-receptor interaction (see bibliography).  His
laboratory is well equipped to support research directed toward
the principle goals of the project requiring protein and peptide
isolation, characterization of FSH-BI by radioreceptor and
radioimmunoassays and by tissue culture.  In addition, the
facilities of a modern Department of Biochemistry will be
available for conduct of the research.  The Chairman of the
Department, Dr. Kelvin Davies, is a recognized molecular
biologist and together with Dr. John Jeffrey (see CV), will
provide the expertise needed in related areas of proposed
research.

## Key facts

- **NIH application ID:** 2194452
- **Project number:** 5K08HD000975-03
- **Recipient organization:** ALBANY MEDICAL COLLEGE
- **SAM.gov UEI:** G6VVMPNK4Y48
- **Principal Investigator:** DANIEL W LEE
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $75,600
- **Award type:** 5
- **Project period:** 1992-03-01 → 1995-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194452

## Citation

> US National Institutes of Health, RePORTER application 2194452, HUMAN FSH-RECEPTOR BINDING INHIBITORS (5K08HD000975-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194452. Licensed CC0.

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