# CONTROL OF MAMMALIAN OOCYTE DEVELOPMENT

> **NIH NIH K04** · MARQUETTE UNIVERSITY · 1994 · $68,040

## Abstract

The long-term goals of my research program are to identify molecules and
metabolic pathways that participate in the regulation of oocyte and
embryo development in mammals.  In the next five years my laboratory will
be focusing on the relationship between energy utilization and regulation
of meiotic maturation in isolated cumulus cell-enclosed mouse oocytes.
We will examine how carbohydrates are metabolized during gonadotropin
stimulation of oocyte maturation and assess the relative importance of
glycolysis and the tricarboxylic acid cycle.  A portion of this work
includes collaboration with a scientist in England involving microassay
of carbohydrate-metabolizing enzymes in individual oocytes.

My earlier education included training in microscopy and morphology as
a graduate student and in reproductive physiology as a postdoctoral
associate.  I have not had practical technical experience with many of
the advances in molecular biology that have been made in the past decade.
It is thus a goal of mine to gain expertise in a number of these
techniques, thereby enabling me to ask more penetrating questions
concerning the physiology of oocytes and embryos.  Due to a 50% time
commitment to teaching at Marquette University, there is no lengthy
period of time during the year that I can set aside for pursuit of
technical training.  with a Research Career Development Award, my
research effort would be increased to 90%, providing nearly 11 months for
full-time research.  This would pay tangible dividends in collaboration
opportunities, not only with members of the Biology Department here at
Marquette, but also with other scientists in the nearby vicinity as well
as abroad.

## Key facts

- **NIH application ID:** 2194519
- **Project number:** 5K04HD001004-02
- **Recipient organization:** MARQUETTE UNIVERSITY
- **SAM.gov UEI:** HKJCKTFJNBM7
- **Principal Investigator:** STEPHEN M DOWNS
- **Activity code:** K04 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $68,040
- **Award type:** 5
- **Project period:** 1993-01-01 → 1997-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194519

## Citation

> US National Institutes of Health, RePORTER application 2194519, CONTROL OF MAMMALIAN OOCYTE DEVELOPMENT (5K04HD001004-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194519. Licensed CC0.

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