# IN VIVO NEONATAL CEREBRAL HEMODYNAMICS AND ENERGETICS

> **NIH NIH K11** · BOSTON CHILDREN'S HOSPITAL · 1994 · $78,300

## Abstract

Brain injury in premature is an important clinical problem due to the
increasing number of surviving premature infants and the high incidence
of neurodevelopmental handicaps in this population.  Disturbances of
cerebral blood flow (CBF) and oxygen delivery are thought to be crucial
factors in neonatal brain injury.  However, the exact mechanisms and
timing of injury are not understood.  In vivo Near infrared spectroscopy
(NIRS) provides a means of direct and continuous bedside monitoring of
neonatal cerebral hemodynamics and oxygenation. NIRS may be able to
detect alterations of cerebral oxygenation or hemodynamics before injury
from cellular energy depletion of this technology in the prevention of
newborn brain injury will required further laboratory based and clinical
studies.  The goal of this proposal is for the PI to become an
independent investigator capable of approaching questions in newborn
neurology with both laboratory and clinical research tools.  To achieve
this goal, the PI has established an in-depth program of didactic and
research training.  In Phase I, the PI will use the response to hypoxia
and ischemia in neonatal piglets 1) to characterize changes in brain Hb02
and Hb concentration, 2) to compare NIRS CBV measurements CBF estimations
to microsphere measures of CBF, 3) to determine the correlation of NIRS
measures of cerebral hemodynamics to magnetic resonance measures cerebral
energy state, and 4) to determine the ability of NIRS cerebral blood
volume measurements predict loss of cerebrovascular regulation.  In phase
II, the findings of the animal studies will be applied i a clinical study
of premature neonates to examine in control and critically ill neonates
1) regulations of CBF, 2) presence or absence of NIRS changes associated
with cerebral energy failure in phase I studies, and 3) differences in
the variability of cerebral hemodynamic parameters.  These will determine
the physiological significance of NIRS with measurements and whether
changes in cerebral oxygenation and blood volume thought to be associated
with increased risk of brain injury are present in critically ill
neonates.  The overall program will provide the necessary baseline data,
logistics, and training in state-of-the-art in-vivo spectroscopy for the
PI to undertake further studies of the relationship between NIRS
measurements of altered cerebral hemodynamics nd subsequent brain injury.

## Key facts

- **NIH application ID:** 2194529
- **Project number:** 1K11HD001010-01A1
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **SAM.gov UEI:** Z1L9F1MM1RY3
- **Principal Investigator:** MILES K TSUJI
- **Activity code:** K11 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $78,300
- **Award type:** 1
- **Project period:** 1993-12-01 → 1998-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194529

## Citation

> US National Institutes of Health, RePORTER application 2194529, IN VIVO NEONATAL CEREBRAL HEMODYNAMICS AND ENERGETICS (1K11HD001010-01A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194529. Licensed CC0.

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