# GROWTH FACTORS IN HUMAN FETAL OOGENESIS

> **NIH NIH K08** · BRIGHAM AND WOMEN'S HOSPITAL · 1994 · $81,540

## Abstract

The transformation of germ cells into primordial follicles in the human
fetus, then into the follicles of the ovary, represents an important and
relatively little understood process.  Although microscopic descriptions
of the changes in the number of oogonia are available, the actual factors
which may regulate cell growth, angiogenesis, apoptosis and pattern
formation are unclear.  The broad long-term objectives of this proposal
are (1) to clarify the role of peptide growth factors as signals/agents
for growth and differentiation in human fetal ovaries and (2) to
understand how peptide growth factors may contribute to abnormalities in
adults ovaries.  The research proposed for this application is intended
to accomplish these goals:

. Specific Aim 1.  Quantitative analysis of mRNA for growth factors and
their receptors during the process of human fetal oogenesis.

. Specific Aim 2.  Localization by immunohistochemistry and in situ
hybridization of growth factors and their receptors in human fetal
ovarian development.

. Specific Aim 3.  To investigate the gene expression of growth factors
and their receptors and to investigate apoptosis in chromosomally
abnormal fetal ovaries.

. Specific Aim 4.  Morphological analysis of development of oogonia and
surrounding cells in fetal ovaries.

## Key facts

- **NIH application ID:** 2194542
- **Project number:** 5K08HD001016-03
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **SAM.gov UEI:** QN6MS4VN7BD1
- **Principal Investigator:** JOHN YEH
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $81,540
- **Award type:** 5
- **Project period:** 1993-07-01 → 1998-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194542

## Citation

> US National Institutes of Health, RePORTER application 2194542, GROWTH FACTORS IN HUMAN FETAL OOGENESIS (5K08HD001016-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194542. Licensed CC0.

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