# CHEMOATTRACTIONS IN REPRODUCTIVE TISSUES

> **NIH NIH K08** · YALE UNIVERSITY · 1994 · $84,510

## Abstract

Macrophages and granulocytes are present in reproductive tissues where
they participate in and affect many aspects of ovarian and u tetrine
function.  The hypothesis to be tested in this proposal is that leukocyte
migration in the ovaries is hormonally regulated and this regulation
occurs through modulation of chemotactic factors.  Based on the
applicant's preliminary results the focus of this research will be study
the physiologic relevance of chemotactic factors for the recruitment and
activation of macrophages and neutrophils in the ovary.  Regulation of
the traffic of leukocytes by chemoattractant, such as interleukin-8 that
acts on neutrophils and monocyte chemotactic protein-1 that acts on
monocyte/macrophages, followed by the secretion of specific paracrine
factors by the leukocytes may be one of the ways by which certain
reproductive events such as ovulation and luteal function are controlled.
Based on our hypothesis, the long-range goal of this research is to
define bimolecular events modulating the expression of these factors in
humans.  To accomplish this goal and to provide optimal opportunity for
the applicant to perfect the investigative skills necessary for
independent research, we propose three specific aims as follows: Specific
Aim 1.  To identify and characterize the functional significance of
specific chemotactic factors (IL-8 and MCP-1) in reproductive physiology
using a rodent model.  Specific Aim 2.  To identify and characterize in
humans the presence and variations of the expression of these
chemoattractant (IL-8 and MCP-1) in the ovaries throughout the menstrual
cycle and during pregnancy.  Specific Aim 3.  To investigate the in vitro
regulation of the expression of these chemoattractant by gonadal steroid
hormones, growth factors and cytokines.  A definition of the bimolecular
events related to chemoattraction of migratory cells relevant to
ovulation and luteal function will be important in advancing our
understanding of these aspects of reproductive biology.  We believe that
series of focused investigations that explore the physiologic relevance
of the chemoattractant factors in regulating the chemotaxis and
activation of macrophages and neutrophils in reproductive tissues may
reveal new insights into the etiology  of ovulatory dysfunctions,
infertility and early pregnancy losses.

## Key facts

- **NIH application ID:** 2194583
- **Project number:** 1K08HD001041-01A1
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** AYDIN M ARICI
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $84,510
- **Award type:** 1
- **Project period:** 1994-04-01 → 1999-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194583

## Citation

> US National Institutes of Health, RePORTER application 2194583, CHEMOATTRACTIONS IN REPRODUCTIVE TISSUES (1K08HD001041-01A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194583. Licensed CC0.

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