# EMBRYONIC PHAGOCYTOSIS IN MOUSE MORPHOGENESIS

> **NIH NIH K11** · UNIVERSITY OF WASHINGTON · 1994 · $76,312

## Abstract

Birth defect syndromes are the leading cause of infant morbidity and
mortality in the United States.  Currently, only a small fraction of
these syndromes are understood at the cell and molecular level.  In order
to understand abnormal human development investigators must characterize
normal morphogenetic processes.  Our long-term goals are to begin to
understand the etiology of human birth defect syndromes by investigating
the cell and molecular mechanisms of normal mouse development.

Phase I of the physician Scientist Training program consists of basic
science training through didactic coursework, laboratory rotations, and
selected seminars, which will serve as the basis for a Ph. D in the
Department of Biological Structure (Anatomy), University of Washington
School of Medicine.  The purpose of this Phase I training is to give the
candidate a solid foundation in basic science in preparation for becoming
an independent investigator in the fields of developmental biology and
human development.

Phase II of this proposal will include in depth investigation into the
role of a population of phagocytic cells in normal mouse morphogenesis.
Four specific aims will be used to test the hypothesis that normal
mammalian development relies on a population of embryonic phagocytes,
responsive to macrophage colony stimulating factor (M-CSF), for normal
morphogenesis of tissues undergoing cell death and remodeling.  This
hypothesis will be tested with the use of immunohistochemistry and in
situ hybridization to localize embryonic phagocytes, and characterized
the expression patterns of M-CSF and its receptor c-fms, in four mouse
strains.  The strains investigated will include the M-CSF deficient
op/op, and three strains with aberrant programmed cell death in regions
of tissue remodeling (CL/Fr, Os/+, and Xpl).  These investigations will
serve to characterize the role of embryonic phagocytes, M-CSF and c-fas
in normal mammalian development.

## Key facts

- **NIH application ID:** 2194605
- **Project number:** 1K11HD001054-01
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** MICHAEL L CUNNINGHAM
- **Activity code:** K11 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $76,312
- **Award type:** 1
- **Project period:** 1993-12-01 → 1998-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194605

## Citation

> US National Institutes of Health, RePORTER application 2194605, EMBRYONIC PHAGOCYTOSIS IN MOUSE MORPHOGENESIS (1K11HD001054-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194605. Licensed CC0.

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