# REGULATION OF GROWTH IN NEONATES BY SUBSTRATE SUPPLY

> **NIH NIH K11** · UNIVERSITY OF COLORADO DENVER · 1994 · $79,403

## Abstract

The long-term goal of this PSA proposal is to develop fundamental basic
science and clinical research skills which will enable the applicant to
develop an independent research career in the areas of nutritional
metabolism, indirect calorimetry and, tracer methodology.  Phase 1 focuses
on developing the background, technical skills and instrumentation in
several distinct fields to successfully perform the clinical studies in
Phase 2.  Phase 1 will establish basic science laboratory skills in cell
culture and amino acid metabolism using tracer techniques and enzyme
determinations.  Specifically, the precursors and enzyme activities of
fetal hepatic serine biosynthesis through the glycolytic pathways in
normal and growth retarded fetuses will be identified.  Didactic training
will focus on nutrition, statistics and the theoretical and technical
aspects of mass spectrometry.  In addition, laboratory validation of
indirect calorimetry under conditions of supplemental oxygen and
mechanical ventilation will be performed.  Phase 2 will focus on
nutritional studies in neonates weighing less than 1000 g, extremely-low-
birthweight (ELBW) infants. The optimal strategy for supplying nutrition
to these infants is poorly defined because of limited information on their
substrate metabolism.  In the recently published NICHD Executive Summary
of its proposed five-year nutrition research plan, there is a recognition
of suboptimal nutrition in the ELBW infant, and of the need for further
investigation in this area, particularly in the first days of life.  We
propose to study protein kinetics and the effects of the quality of the
infused energy on protein metabolism in the ELBW infant in the first 48
hours of life using stable isotope methodology combined with indirect
calorimetry.  In longitudinal studies, we will assess changes in protein
metabolism in ELBW infants in the first 2 weeks of life.  These studies
are designed to extend the ability to study metabolism in ELBW infants,
and to provide information on substrate kinetics that will be critical to
developing rational nutritional strategies for the ELBW infant.

## Key facts

- **NIH application ID:** 2194620
- **Project number:** 5K11HD001061-02
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **SAM.gov UEI:** MW8JHK6ZYEX8
- **Principal Investigator:** PATTI THUREEN
- **Activity code:** K11 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $79,403
- **Award type:** 5
- **Project period:** 1993-08-01 → 1998-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194620

## Citation

> US National Institutes of Health, RePORTER application 2194620, REGULATION OF GROWTH IN NEONATES BY SUBSTRATE SUPPLY (5K11HD001061-02). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/2194620. Licensed CC0.

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