# RETINOIC ACID AND TERATOLOGY

> **NIH NIH K04** · TEMPLE UNIV OF THE COMMONWEALTH · 1994 · $69,660

## Abstract

The goals of my research are to understand the molecular events
associated with retinoic acid-induced teratogenesis.  To achieve this
end, my immediate needs are to broaden my research skills, in part
through interactions with other researching prominent approaches and
refine the techniques I currently use, as well as to continue to grow in
the ability to critically analyze research problems and concepts, and to
develop innovative experimental designs.

This award will significantly reduced my teaching and service
responsibilities to no more than 10 to 15% of my time so that I can
concentrate almost exclusively on research activity within my own
laboratory, for the continuation, development, and enhancement of
collaborations within Temple University and with scientists at other
institutions.  In addition, it will provide additional time and monies
for travel to meetings, workshop and individual laboratories to enhance
my research career and program.

Temple University School of Medicine agrees to reduce my teaching and
service responsibilities so that they will be no more than 10 to 15% of
my time and to provide me with sufficient space, full use of equipment
and shared resources and abilities to purchase and maintain specialized
equipment to enhance my research program.  Departmental budget will not
be reduced because of this award assuring that at the end of this award
the School of Medicine shall resume financial obligation for full payment
of salary and fringe benefits at a level commensurate with meritorious
continuous service to the institution.

Research proposed in this application deals with the identification and
characterization of the role of ANALYZE-Beta in both normal and
teratogenic development.  More specifically using a variety of molecular
biology approaches, I will study the molecular regulation and
morphological consequences of ANALYZE-beta expression during development
in mouse embryos treated with normal and teratogenic doses of retinoic
acid.

## Key facts

- **NIH application ID:** 2194653
- **Project number:** 1K04HD001076-01
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **SAM.gov UEI:** QD4MGHFDJKU1
- **Principal Investigator:** DIANNE R SOPRANO
- **Activity code:** K04 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $69,660
- **Award type:** 1
- **Project period:** 1994-06-01 → 1999-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194653

## Citation

> US National Institutes of Health, RePORTER application 2194653, RETINOIC ACID AND TERATOLOGY (1K04HD001076-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194653. Licensed CC0.

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