# NUCLEAR RECEPTORS IN VERTEBRATE CRANIOFACIAL DEVELOPMENT

> **NIH NIH K08** · BAYLOR COLLEGE OF MEDICINE · 1994 · $78,186

## Abstract

My long term career objective is to conduct independent, clinically
relevant basic science research. My research interests are in the
molecular mechanisms that underlie development of the craniofacial
tissues. Craniofacial abnormalities affect hundreds of thousands of
children each year causing physical, emotional and economic hardships for
the child and their families. It has been recognized for over 50 years
that deficiencies, and excesses, in vitamin A or its biological
metabolite, retinoic acid, is associated with severe craniofacial defects.
These defects frequently include cleft lip and palate, and malformations
of the middle and external ear. Although the precise molecular mechanisms
that underlie this process remains poorly understood, these studies are,
highly suggestive of a role for a nuclear receptor such as RA and its
receptor in craniofacial development. In this proposal, I will study the
role of nuclear receptors in one of the earliest events in formation of
the craniofacial structures, hindbrain segmentation. We will isolate
nuclear receptors expressed during early vertebrate neurogenesis, and
describe their temporal and spatial patterns of expression using in situ
analysis. We will also investigate the effects of cell interactions on
nuclear receptor gene expression using transplantation experiments.

## Key facts

- **NIH application ID:** 2194659
- **Project number:** 1K08HD001079-01
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **SAM.gov UEI:** FXKMA43NTV21
- **Principal Investigator:** Jill A Helms
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $78,186
- **Award type:** 1
- **Project period:** 1994-05-01 → 1999-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194659

## Citation

> US National Institutes of Health, RePORTER application 2194659, NUCLEAR RECEPTORS IN VERTEBRATE CRANIOFACIAL DEVELOPMENT (1K08HD001079-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194659. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*