# PHYSIOLOGICAL STUDY OF THE PLACENTA

> **NIH NIH R37** · UNIVERSITY OF COLORADO DENVER · 1994 · $276,706

## Abstract

Long-term objective is knowledge of the factors that determine
and regulate the metabolic exchange between mother, placenta,
and fetus.  The solution of important health related problems,
such as detection and prevention of fetal hypoxia, malnutrition,
and growth disorders, depends on the acquisition of this basic
knowledge.  The specific aims are:  (1) to study placental oxygen
transport in twin-pregnant ewes that carry hemoglobins with
different oxygen affinities.  (2) to study developmental changes
in placental glucose transport,  (3) to test  the hypothesis that
the serine metabolized by the placenta is primarily of fetal
origin.  (4) to study the effect of undernutrition on
uteroplacental metabolism and placental oxygen transport, and (5)
to study mechanisms of fetal lactate and pH regulation in a
controlled sae of fetal hypoxia associated with a significant
decrease in fetal oxygen uptake.  The studies will be performed
in chronic sheep preparations.  The maternal-placental-fetal
exchange will be quantitated by using techniques of blood flow
measurement, chemical analysis of maternal arterial, uterine
venous, umbilical arterial and venous blood, and tracer
methodology.

## Key facts

- **NIH application ID:** 2194776
- **Project number:** 5R37HD001866-29
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **SAM.gov UEI:** MW8JHK6ZYEX8
- **Principal Investigator:** GIACOMO MESCHIA
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $276,706
- **Award type:** 5
- **Project period:** 1977-02-01 → 1998-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194776

## Citation

> US National Institutes of Health, RePORTER application 2194776, PHYSIOLOGICAL STUDY OF THE PLACENTA (5R37HD001866-29). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194776. Licensed CC0.

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