# HORMONAL REGULATION OF BEHAVIOR

> **NIH NIH R01** · RUTGERS THE STATE UNIV OF NJ NEWARK · 1993 · $113,124

## Abstract

The long-term of objective of this project is to understand interactions
between noradrenergic neurotransmission and steroid responsive brain areas
and to relate these interaction to regulation of female reproductive
behaviors. Specific aims are (a) to stereotaxically implant in specific
brain nuclei drugs which are antagonists or agonists of alpha-receptor
subtypes that normally respond to norepinephrine. this set of experiments
is aimed at localizing alpha noradrenergic receptor subtypes involved in
regulation of female reproductive behavior, (b) to determine the effects of
pharmacological blockade of alpha-1 and alpha-2 noradrenergic receptor
subtypes on concentrations of progestin, estrogen and androgen receptors in
microdissected brain nuclei involved in reproduction. The object of these
experiments is to develop a model by which altered noradrenergic subtypes
is present in cells which contain estrogen and progestin receptors in brain
areas known to mediate female reproduction and (d) to determine whether
pharmacological manipulation of noradrenergic transmission during the
prenatal period of sexual differentiation of the brain results in permanent
changes in concentrations of brain steroid receptors and in permanent
changes in reproductive capacity.

All of these studies utilize the guinea pig. Study of this species has
revealed clear-cut effects of noradrenergic transmission on female
reproductive behavior and on the various classes of brain steroid
receptors.

Understanding of interactions of noradrenergic system with steroid-
sensitive brain areas is important for developing a clearer picture of
brain mechanisms involved in human reproduction and in catecholamine-
steroid interactions that may be involved in mood disorders. Possible
prenatal effects of noradrenergic system alterations on adult because they
may point to disturbances in this neurotransmitter system as an important
etiological factor in human reproductive function deficiencies and perhaps
in non-reproductive functions and behaviors as well.

## Key facts

- **NIH application ID:** 2194860
- **Project number:** 5R01HD004467-22
- **Recipient organization:** RUTGERS THE STATE UNIV OF NJ NEWARK
- **SAM.gov UEI:** T3NGNR66YK89
- **Principal Investigator:** HARVEY H FEDER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $113,124
- **Award type:** 5
- **Project period:** 1977-05-01 → 1995-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194860

## Citation

> US National Institutes of Health, RePORTER application 2194860, HORMONAL REGULATION OF BEHAVIOR (5R01HD004467-22). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194860. Licensed CC0.

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