# OOGENESIS AND GENE CONTROL IN ANIMAL REPRODUCTION

> **NIH NIH R37** · CALIFORNIA INSTITUTE OF TECHNOLOGY · 1994 · $956,189

## Abstract

This proposed research program is a direct extension of our earlier
program with the same 1 fundamental goals:  the investigation of
reproduction, and the molecular mechanisms that control genetic
activity.  Specific aims include:  determination of the biological
significance of the individual cis regulatory sites of Cyllla and
SM50 genes; cloning, characterization, and studies on the
localization and synthesis of the trans regulatory factor directing
expression of these genes; exploration of upper levels of the
regulatory control hierarchy, including search for elements shared
amongst coordinately controlled genes; experiments on normal and
chimeric embryos using molecular probes to investigate induction
and localization in early development; extension of knowledge of
specification and cell lineage in the embryo, and determination of
the origin of lineage elements using imaginal rudiments; carrying
out studies on transcription in oogenesis:  utilizing evolutionary
change and conservation in sequences important for developmental
gene regulation for assessment of functional significance;
development of paradigms for photoperiodic control of gonadal cycle
in cultured sea urchins producing and characterizing inbred lines
of laboratory sea urchins, and attempting to-induce and exploit
hermaphroditism for research purposes.

## Key facts

- **NIH application ID:** 2194916
- **Project number:** 4R37HD005753-25
- **Recipient organization:** CALIFORNIA INSTITUTE OF TECHNOLOGY
- **SAM.gov UEI:** U2JMKHNS5TG4
- **Principal Investigator:** ERIC H DAVIDSON
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $956,189
- **Award type:** 4N
- **Project period:** 1974-05-01 → 1999-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2194916

## Citation

> US National Institutes of Health, RePORTER application 2194916, OOGENESIS AND GENE CONTROL IN ANIMAL REPRODUCTION (4R37HD005753-25). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2194916. Licensed CC0.

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