# ENVIRONMENTAL AND HORMONAL INTERPLAY OF OVULATION

> **NIH NIH R01** · NORTHWESTERN UNIVERSITY · 1994 · $176,971

## Abstract

DESCRIPTION (Adapted from applicant's abstract):  The objectives of this
project are to investigate the factors that differentially regulate the
storage, synthesis, and secretion of the gonadotropins, LH and FSH.  Five
interrelated specific aims are proposed.  The first is to discover the site
of delay in LH rise in female rats in response to removal of gonadal
negative feedback.  In vitro tests of hypothalami in a perifusion culture
system will be used to determine whether there is a sex difference in GnRH
secretion post-gonadectomy.  The second aim is to examine pituitary,
gonadal, and adrenal factors which regulate inhibin synthesis and
secretion.  The third aim is to discover the role of progesterone feedback
on differential LH/FSH secretion using the progesterone receptor antagonist
RU486.  The fourth aim is to study the site of glucocorticoid differential
regulation of LH and FSH synthesis and secretion.  An ectopic pituitary
transplant model will be used to examine whether the pituitary is the site
of suppression by glucocorticoids of the response of LH to GnRH.  The fifth
aim is to investigate the site of action of hyperprolactinemia in the
preferential suppression of LH over FSH secretion.

## Key facts

- **NIH application ID:** 2195815
- **Project number:** 5R01HD007504-20
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **SAM.gov UEI:** EXZVPWZBLUE8
- **Principal Investigator:** NEENA B SCHWARTZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $176,971
- **Award type:** 5
- **Project period:** 1977-06-01 → 1996-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2195815

## Citation

> US National Institutes of Health, RePORTER application 2195815, ENVIRONMENTAL AND HORMONAL INTERPLAY OF OVULATION (5R01HD007504-20). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2195815. Licensed CC0.

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