# SEX CHROMOSOMAL ABNORMALITIES:  A PROSPECTIVE STUDY

> **NIH NIH R01** · NATIONAL JEWISH HEALTH · 1994 · $140,179

## Abstract

The long-term objectives of this study are to continue to establish the
developmental prognosis into adulthood of individuals with sex chromosome
abnormalities (SCA) identified at birth in an unselected fashion between
1964 and 1974.  In the course of this longitudinal study, we have
documented the physical, endocrine, developmental, and psychological
phenotypes of SCA children.  The presence of language, learning, and
neuromotor impairment in SCA children and of psychosocial dysfunction in
SCA adolescents suggests that SCA adults are at risk for difficulty in
social and vocational adaptation and may experience increased incidence
of psychopathology.  No studies of an unselected SCA adult cohort are in
existence, and the absence of any newborn sex chromosome screening
programs in the past two decades indicates that the Denver Study will be
the first and possibly last foreseeable opportunity to study adult
adaptation in this population.  This proposal includes investigations of
physical, endocrine, neurocognitive, vocational, and psychosocial
characteristics of 42 SCA propositi and a control group that includes 32
siblings.  The specific aims allow us to address questions raised in our
earlier studies of this group and to complete the phenotypic profile from
birth into adulthood of the 45,X, 47,XXX, 47,XXY, and sex chromosome
mosaic karyotypes.

## Key facts

- **NIH application ID:** 2196703
- **Project number:** 5R01HD010032-18
- **Recipient organization:** NATIONAL JEWISH HEALTH
- **SAM.gov UEI:** VLQKFEEJ3NE9
- **Principal Investigator:** ARTHUR ROBINSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $140,179
- **Award type:** 5
- **Project period:** 1976-05-01 → 1996-04-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2196703

## Citation

> US National Institutes of Health, RePORTER application 2196703, SEX CHROMOSOMAL ABNORMALITIES:  A PROSPECTIVE STUDY (5R01HD010032-18). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2196703. Licensed CC0.

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