# HORMONAL REGULATION OF SERTOLI CELL MATURATION

> **NIH NIH R01** · WASHINGTON STATE UNIVERSITY · 1994 · $160,189

## Abstract

Sertoli cells are the epithelial "nurse" cells of the testis which along
with the germ cells comprise the seminiferous tubules.  The Sertoli cells
clearly play important although incompletely defined roles in the process
of spermatogenesis.  The long term goals of this project are to
understand the different roles of the Sertoli cells in spermatogenesis.
These goals relate directly to human health problems dealing with
reproductive infertility and may lead to new approaches to contraception.
In the past grant periods this project has focused on the
characterization of Sertoli cell secretion products and their specific
roles in spermatogenesis.  In the next grant period we propose logical
and focused extensions of our previous studies, and, in addition, propose
some new approaches to understanding how Sertoli cells products influence
germ cells.  The specific aims for the next grant period include: 1. The
identification and characterization of regulatory elements on the FSH
receptor (FSHR) gene promoter. 2. Identification of agents which regulate
the expression of the FSH receptor in Sertoli cells in culture and in
vivo. 3. Successful direction of transgenes into the Sertoli cells of
transgenic mice.  We hope that this last aim will lead to ways to
specifically alter the expression of genes in Sertoli cells in vivo.

## Key facts

- **NIH application ID:** 2196752
- **Project number:** 5R01HD010808-17
- **Recipient organization:** WASHINGTON STATE UNIVERSITY
- **SAM.gov UEI:** XRJSGX384TD6
- **Principal Investigator:** MICHAEL D GRISWOLD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $160,189
- **Award type:** 5
- **Project period:** 1977-08-01 → 1997-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2196752

## Citation

> US National Institutes of Health, RePORTER application 2196752, HORMONAL REGULATION OF SERTOLI CELL MATURATION (5R01HD010808-17). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2196752. Licensed CC0.

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