# DIABETES DURING PREGNANCY:  EFFECTS ON THE OFFSPRING

> **NIH NIH P50** · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · 1994 · $828,007

## Abstract

This revised competitive renewal will have five subprojects that deal with
the various aspects of diabetes complicating pregnancy.  Subproject 1 will
investigate the independent effects of pregnancy and exercise training on
early phase insulin release in non-diabetic women and those with prior
gestational diabetes.  Subproject 2 will examine the growth and development
of infants born to gestational diabetics.  Subproject 3 is to evaluate the
impact of postnatal nutrition on growth and development of infants with
fetal growth retardation.  This project will evaluate the role of
psychosocial intervention in improving the nutritional and developmental
outcome of infants with intrauterine growth retardation.  Subproject 4 will
test the hypothesis that systemic hypoglycemia and hyperglycemia will
result in circulatory, metabolic and blood brain barrier permeability
changes, which may place the fetus and neonate at higher risk for hypoxic-
ischemic injury, and/or other CNS injury.  Subproject 5 will examine the
cellular regulatory mechanism of fetal growth and development.  The major
emphasis is to examine the contribution of maternal IGF on embryonic IGF
and TGF-B gene expression and fetal differentiation.  This PERC consists of
five projects with 18 investigators of various disciplines that will
examine the various aspects of fetal growth: the role of IGF on fetal
growth and differentiation, the effects of fetal growth abnormalities, i.e.
macrosomic and intrauterine growth retardation, and the effects of exercise
on glucose metabolism during pregnancy.

## Key facts

- **NIH application ID:** 2196798
- **Project number:** 5P50HD011343-17
- **Recipient organization:** WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
- **SAM.gov UEI:** VUYJL5Q7YCZ3
- **Principal Investigator:** WILLIAM OH
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $828,007
- **Award type:** 5
- **Project period:** 1977-12-01 → 1996-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2196798

## Citation

> US National Institutes of Health, RePORTER application 2196798, DIABETES DURING PREGNANCY:  EFFECTS ON THE OFFSPRING (5P50HD011343-17). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2196798. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*