# DIABETES IN PREGNANCY

> **NIH NIH P01** · UNIVERSITY OF CINCINNATI · 1993 · $1,331,593

## Abstract

The long term objective of the Program Project Grant Diabetes in Pregnancy
III, is to decrease maternal & mortality in diabetic pregnancy. The major
theses is that maternal glucose control & reduction of fetal
hyperinsulinism reduce metabolic & functional disturbances in mother &
fetus. Section A Drs. Miodovnik, Berk, Ballard, Dignan, & Tsong conduct a
core clinical trial: continuing a unique prospective randomized trial of
strict glycemic control vs less strict control, beginning in the first 9
weeks vs late entry, & a control group. The thesis is: strict early
control reduces maternal complications, early fetal loss, malformations, &
neonatal morbidity & mortality. A 1) Drs. Berk & Miodovnik test the
thesis: impaired adrenergic conterregulatory response to hypoglycemic
increases frequency & severity of hypoglycemia in pregnancy; strict
glycemic control results in frequent & severe hypoglycemia & impaired
adrenergic counferregulation. A2) Drs. Sperling, Mimouni & Compaigne test
the thesis: hyperplastic fetal islets results in long term insulin
hyperresponsiveness to secretagogues including glucose; & persistent
hyperinsulinemic responsiveness induces insulin resistance. A3) Drs.
Mimouni, Tsang & Ross test the thesis: maternal diabetic magnesium
deficiency may result in neon(ital hypoporathyroidism, magnesium
administration in infants results in higher magnesium, parathyroid &
calcium, but similar 1,25(OH)2 D. A4) Drs. Berk & Lipman will study the
short & long-term consequences of pregnancy on diabetic microvascular
complications. Section B Dr. Richardus Ross directs a core alloxan
diabetic pregnant sheep model. B1) Drs. Ross, Mimouni & Tsong test the
thesis that maternal 1,25-vitamin D production is impaired in diabetic
pregnancy, leads to decreases in intestinal calcium absorption, bone
turnover & placental calcium transfer. Adaptive fetal responses include
enhanced 1,25-vitamin D production & decreased bone mineralization. B2)
Drs. Whitsett & Korfhagen test the thesis: insulin dependent inhibition of
the SP-B gene is cis-active & maps in or near the SAP gene promoter:
Clinical sheep studies of SPA & SP-B expression in IDM will provide in
vivo correlates of molecular studies. B3) Dr. Cuppoletti tests the thesis:
insulin in the fetus: increases glucose transport protein complement &
glucose transport in isolated cardiac myocytes; & "triggers" synthesis of
MRNA for new D-glucose carrier proteins. B4) Dr. Sperling will apply the
Fick principle & isotope dilution in-normal & diabetic pregnant sheep with
catheterized fetal, utero-placental & maternal circulations comparing
glucose, fructose & leucine metabolism & their potential contribution to
fetal energy & growth. Section C, Drs. Tsong, Sperling, Campaigne & Ms.
Gratton provide administrative organization. CI The Core  biostatistics
group, Drs. Hertzberg & Buncher provide integrated support for all
studies. In this PPG,basic & clinical studies complement each other in an
integrated, multidiscipli...

## Key facts

- **NIH application ID:** 2196833
- **Project number:** 5P01HD011725-15
- **Recipient organization:** UNIVERSITY OF CINCINNATI
- **SAM.gov UEI:** DZ4YCZ3QSPR5
- **Principal Investigator:** REGINALD C TSANG
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $1,331,593
- **Award type:** 5
- **Project period:** 1978-06-01 → 1995-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2196833

## Citation

> US National Institutes of Health, RePORTER application 2196833, DIABETES IN PREGNANCY (5P01HD011725-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2196833. Licensed CC0.

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