# SELECTIVE INHIBITORS OF PLACENTAL STEROID AROMATASE

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 1993 · $166,362

## Abstract

The objectives of this proposal include the design, synthesis an
devaluation of specific inhibitors of human placental aromatase (estrogen
synthetase).  These inhibitors include enzyme-generated irreversible
inhibitors and also competitive reversible inhibitors.  Specific inhibitors
of human biosynthesis in placental tissue and in other tissues.  They may
also be of value in the study and treatment of estrogen-dependent tumors,
and in studying the role played by peripheral aromatization of androgen in
male endocrinology.

Mechanistic studies with these inhibitors should be of interest in further
examination of the mechanism of action of aromatase.  Covalent labeling of
purified enzyme by radiolabeled inhibitors may provide valuable information
about the enzyme's active site.  A chemical model for aromatase has been
developed, and this model will be evaluated in terms of the enzymatic
process's stereochemical and kinetic behavior.

## Key facts

- **NIH application ID:** 2196846
- **Project number:** 5R01HD011840-15
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **SAM.gov UEI:** FTMTDMBR29C7
- **Principal Investigator:** CECIL H ROBINSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $166,362
- **Award type:** 5
- **Project period:** 1978-09-01 → 1995-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2196846

## Citation

> US National Institutes of Health, RePORTER application 2196846, SELECTIVE INHIBITORS OF PLACENTAL STEROID AROMATASE (5R01HD011840-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2196846. Licensed CC0.

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