# NEUROENDOCRINE-METABOLIC CONTROL OF THE MENSTRUAL CYCLE

> **NIH NIH P50** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 1994 · $944,569

## Abstract

The research projects proposed here are closely interrelated and have
evolved from past research productivity and collaboration.  The common aim
of the six research units (4 cores) is to expand our knowledge of the
neuroendocrine-metabolic regulation of reproductive function and its
disorders in women.  Cellular, biochemical and genomic mechanisms will be
explored through the use of a variety of in vitro and in vivo techniques,
in which both animal and human tissue and cells will be employed.  Animal
experimentation will be conducted for those studies which are not feasible
with human subjects such as the molecular analysis of the regulation of the
follicle-stimulating hormone beta-subunit gene (Mellon, Unit 2), and
factors controlling follicular atresia (Erickson, Unit 3).  Parallel
studies in animal and human tissues with or without prior in vivo
treatments will be conducted to define the paracrine/autocrine function of
inhibin-related peptides.  The strategy for the investigation in humans is
to circumvent the inherent limitations by selecting disease states to serve
as "nature made" experiments and to provide a compliment to physiological
studies in normal human subjects and the laboratory based experiments in
animals.  Studies of neuroendocrine-metabolic control of the human
menstrual cycle will be focused on conditions with aberrations of the link
between the brain and ovary and between peripheral metabolic disorders and
the reproductive axis such as functional hypothalamic amenorrhea and
polycystic ovary syndrome (Yen, Unit 1).  The cellular mechanisms of
insulin resistance and tissue specificity, particularly the postreceptor
defects as they relate to hyperinsulinemic chronic anovulation of
polycystic ovary syndrome will be defined (Olefsky/Ciraraldi, Unit 5).
Finally, multiple interactions and collaborations between and among units
and cores are planned.  This attribute of our Center can be exemplified by
the attempt to clone human GnRH receptor CDNA (Unit 1) followed by binding,
expression and regulation studies using RNA derived from the gonadotrope
cell line and dispersed human pituitary cells Core C-Unit 1).  The
participants in this proposed research Center have been selected not only
because of the commonality of their interests but also because of their
acknowledged expertise in their respective fields.

## Key facts

- **NIH application ID:** 2196889
- **Project number:** 5P50HD012303-16
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **SAM.gov UEI:** UYTTZT6G9DT1
- **Principal Investigator:** SAMUEL S YEN
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $944,569
- **Award type:** 5
- **Project period:** 1978-12-01 → 1998-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2196889

## Citation

> US National Institutes of Health, RePORTER application 2196889, NEUROENDOCRINE-METABOLIC CONTROL OF THE MENSTRUAL CYCLE (5P50HD012303-16). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2196889. Licensed CC0.

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