# GROWTH AND DIFFERENTIATION OF THE PITUITARY GLAND

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 1993 · $130,116

## Abstract

The specific aims are to study the mechanisms of pituitary growth and
differentiation by (1) analyzing cytodifferentiation in the adenohypophysis
in dwarf (dw) and little (lit) mutant mice, (2) examining cellular kinetics
in the postnatal glands of normal mice, and (3) comparing and analyzing
tissue interactions among the adenohypophysis, neurohypophysis, and brain
in mouse and rhesus monkey embryos.  A variety of techniques will be used,
including electron microscopy, morphometry, immunocytochemistry at the
electron microscopic level, and autoradiography.  These studies will
contribute to our understanding of the complex mechanisms involved in
normal and abnormal development of the human pituitary gland, particularly
with respect to pituitary dwarfism and related growth disorders, as well as
to the formation of pituitary adenomas and to various dysplasias involving
pituitary target endocrine organs such as the thyroid gland, adrenal
glands, and gonads.

## Key facts

- **NIH application ID:** 2196898
- **Project number:** 5R01HD012308-09
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **SAM.gov UEI:** UYTTZT6G9DT1
- **Principal Investigator:** DORIS B WILSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $130,116
- **Award type:** 5
- **Project period:** 1991-04-01 → 1995-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2196898

## Citation

> US National Institutes of Health, RePORTER application 2196898, GROWTH AND DIFFERENTIATION OF THE PITUITARY GLAND (5R01HD012308-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2196898. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*