# MODELS IN POPULATION GENETICS

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA BERKELEY · 1994 · $170,968

## Abstract

The genes of the human leukocyte antigen (HLA) region control a variety
Of functions involved in the immune response, and influence
susceptibility to over 40 diseases.  Our understanding of the structure
and function of the HLA genes, their disease associations, and the
evolutionary features of this multigene family has benefitted from recent
advances in molecular biology, immunology, disease modelling and
population genetics.  Theoretical studies in the development of models to
determine the modes of inheritance of the HLA associated diseases have
led to a better understanding of the inheritance patterns in insulin
dependent diabetes mellitus, rheumatoid arthritis, multiple sclerosis,
ankylosing spondylitis, hemochromatosis, celiac disease, and others.  It
is now clear that many of the HLA associated diseases involve
heterogeneity in their HLA components, as well as non-HLA genetic
components.

The specific aims of our research are to study the genetic components in
the etiology of the HLA associated diseases, and population genetic
features of the HLA system.  A variety of methods to test modes of
inheritance of diseases using marker allele information, will be
developed.  Methods appropriate for the analysis of marker systems which
are not highly polymorphic, to both detect linkage and determine modes of
inheritance, will be investigated.  The information content of particular
pedigree types for LOD score analysis will be investigated.  Two methods
using patterns of linkage disequilibrium will be investigated to
determine their usefulness in mapping disease predisposing genes.  A
number of large collaborative data sets of HLA associated diseases will
be analyzed.  A framework for genetic counselling of HLA associated, and
other complex diseases, will be developed.  The results of our studies
are generally applicable to the mapping and characterization of complex
human genetic traits.

## Key facts

- **NIH application ID:** 2196931
- **Project number:** 5R01HD012731-16
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **SAM.gov UEI:** GS3YEVSS12N6
- **Principal Investigator:** GLENYS J THOMSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $170,968
- **Award type:** 5
- **Project period:** 1979-04-01 → 1997-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2196931

## Citation

> US National Institutes of Health, RePORTER application 2196931, MODELS IN POPULATION GENETICS (5R01HD012731-16). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/2196931. Licensed CC0.

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