# FETAL ACTIVITY AND HYPOXIA DURING DEVELOPMENT

> **NIH NIH P50** · COLUMBIA UNIV NEW YORK MORNINGSIDE · 1994 · $1,155,458

## Abstract

The principal goals of this Perinatal Emphasis Research Center are to
examine how the developing fetus responds to hypoxia and to provide better
methods for assessing the condition of the fetus and immature newborn
infant.

A special feature of this center will be studies in the chronically
instrumented pregnant baboon because of similarities in neuro-behavioral
and physiological development among primates. Studies of the integration of
physiological activities into defined states, together with endocrine
function will provide new knowledge unique to the primate and not available
from human investigation. These studies will supply key data for several
other projects relating to regulatory mechanisms for understanding of fetal
pituitary and adrenal function, changes in fetal activity preceding labor,
and the continuum of the regulation of states from fetal to neonatal life.

The goals are encompassed in a multidisciplinary program of seven
interrelated projects, plus two core units which will provide the necessary
administrative assistance and computer expertise for management of data and
analysis required by each project. The research will provide new
information on the mechanism of hypoxic injury to the fetus and will lead
to new methods of assessing fetal well-being. It will also focus on
mechanisms leading to fetal growth retardation as a result-of hypoxia and
the structural and functional consequences of hypoxia on the developing
heart and brain. Knowledge of the regulatory mechanisms of state
organization and patterns of diurnal cyclicity would provide the normal
physiological background necessary for determining whether there is a
disruption in this organization. This could provide a new diagnostic
approach to study the effects of perinatal drug abuse, perinatal brain
damage and a possible neurodevelopmental basis for the sudden infant death
syndrome.

## Key facts

- **NIH application ID:** 2196959
- **Project number:** 5P50HD013063-15
- **Recipient organization:** COLUMBIA UNIV NEW YORK MORNINGSIDE
- **SAM.gov UEI:** F4N1QNPB95M4
- **Principal Investigator:** RAYMOND I. STARK
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $1,155,458
- **Award type:** 5
- **Project period:** 1979-08-01 → 1995-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2196959

## Citation

> US National Institutes of Health, RePORTER application 2196959, FETAL ACTIVITY AND HYPOXIA DURING DEVELOPMENT (5P50HD013063-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2196959. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*