# PEPTIDES AND REPRODUCTION

> **NIH NIH P01** · SALK INSTITUTE FOR BIOLOGICAL STUDIES · 1994 · $1,373,513

## Abstract

The central theme of the program is to evaluate the hypothesis that gonadal
proteins of the inhibin/activin family and neuroendocrine peptides
especially GNRH, oxytocin and CRF and play important roles in the
regulation of reproduction. 'These substances gain access to or are
localized within the pituitary, gonads, placenta and brain where they act
in an endocrine, paracrine or autocrine manner to control the
differentiation, growth and functions of those tissues. In general we have
three goals: (1) To characterize biologically important peptides/proteins,
their precursors and their genes on the chemical and molecular level; (2)
to explore their physiologic and pathophysiologic significance at the
molecular, cellular and system levels-understanding both the control of
peptide expression as well as their mode of action; (3) to develop a I
pharmacology of the peptides that will provide tools for the investigation
of their structures and functions.

This multidisciplinary program brings together specialists in system
physiology, reproduction biology, pharmacology, cell biology, receptor
biology, molecular biology. peptide and protein isolation, analytical
biochemistry, mass spectrometry and synthetic chemistry. The program
comprises five Projects and five Cores which provide administrative,
immunoassay, peptide analysis., purification, and molecular biology
services. The five projects explore the distribution, chemical nature,
regulation of gene expression and physiological roles of inhibin/activin
subunits and other peptides in the gonads, pituitary, placenta and brain.
Concepts and tools developed by this program will continue to contribute to
our understanding of the reproductive, endocrine and central nervous
systems in normal and diseased circumstances and may lead to improved
methods for fertility regulation.

## Key facts

- **NIH application ID:** 2197006
- **Project number:** 5P01HD013527-15
- **Recipient organization:** SALK INSTITUTE FOR BIOLOGICAL STUDIES
- **SAM.gov UEI:** NNJ6BMBTFGN5
- **Principal Investigator:** WYLIE W. VALE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $1,373,513
- **Award type:** 5
- **Project period:** 1980-07-01 → 1995-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197006

## Citation

> US National Institutes of Health, RePORTER application 2197006, PEPTIDES AND REPRODUCTION (5P01HD013527-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197006. Licensed CC0.

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