# SPECIALIZED POPULATION RESEARCH CENTER

> **NIH NIH P50** · POPULATION COUNCIL · 1993 · $970,581

## Abstract

The P50 Specialized Population Research Center described in this proposal
is comprised of five research projects and four core laboratories that will
perform research designed to achieve a broad understanding of testes and
their two major products, germ cells and steroid hormones.  The biology of
newly and recently identified Sertoli cell proteins will provide the basis
for evaluating seminiferous tubular function and for isolating and
sequencing germ cell proteins that regulate Sertoli cells.  A detailed
understanding of the Sertoli cell product, androgen-binding protein (ABP),
will be derived from an analysis of how individual structural changes in
this protein alter its function; following alterations in the ABP cDNA,
mutant ABP produced in vitro will be compared with native ABP so that the
structure of this binding protein can be related to its ability to bind and
activate androgen-responsive cells.  Studies of the promoter regions of the
B-glucuronidase and KAP genes will identify regions of interaction with
androgen receptor and other transcription factors; these experiments will
provide an understanding of how androgen stimulates specific genes in
selected tissues.  Parallel studies of the clusterin gene promoter will
demonstrate how cAMP suppresses accumulation of this mRNA in Leydig and
Sertoli cells; unlike the well-characterized process by which cAMP
stimulates selected genes, the suppressive effect of this intracellular
modulator on transcription has not been elucidated.

## Key facts

- **NIH application ID:** 2197011
- **Project number:** 5P50HD013541-14
- **Recipient organization:** POPULATION COUNCIL
- **SAM.gov UEI:** WKTLM8NNXDW1
- **Principal Investigator:** CLYDE W BARDIN
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $970,581
- **Award type:** 5
- **Project period:** 1980-04-01 → 1997-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197011

## Citation

> US National Institutes of Health, RePORTER application 2197011, SPECIALIZED POPULATION RESEARCH CENTER (5P50HD013541-14). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197011. Licensed CC0.

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