# TESTICULAR RECEPTORS OF FOLLICLE STIMULATING HORMONE

> **NIH NIH R01** · ALBANY MEDICAL COLLEGE · 1994 · $236,745

## Abstract

The overall objective of this project continues understanding at the
molecular level of the interaction the process of signal transduction. FSH
receptor will testis by procedures developed during the recent period of
project support. The receptor will be partially sequenced to allow
preparation of cDNA probes with a view towards cloning of the receptor.
Receptor functionality will be confirmed through use of reconstitution
experiments. We will utilize enzymic and/or chemical fragmentation of the
receptor, together with microsequencing, to identify regions of the
receptor required for interaction with FSH. The role of carbohydrates in
receptor function will be studied, as will be a possible role of
phosphorylation in receptor signal transduction. The significance of the
recently observed thioredoxin (protein disulfide isomerase) activity of
FSH in terms of receptor activation will be probed, as will a possible
function of the FSH receptor as a modulator of calcium ion transport into
Sertoli cells (calcium gating effect). In support of the overall program,
polyclonal and/or monoclonal antibodies will be raised against the
receptor and fragments thereof. A variety of other studies are proposed,
directed toward understanding FSH receptor interaction and signal
transduction, which will be undertaken as circumstances dictate.

## Key facts

- **NIH application ID:** 2197045
- **Project number:** 5R01HD013938-16
- **Recipient organization:** ALBANY MEDICAL COLLEGE
- **SAM.gov UEI:** G6VVMPNK4Y48
- **Principal Investigator:** LEO E REICHERT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $236,745
- **Award type:** 5
- **Project period:** 1979-09-01 → 1996-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197045

## Citation

> US National Institutes of Health, RePORTER application 2197045, TESTICULAR RECEPTORS OF FOLLICLE STIMULATING HORMONE (5R01HD013938-16). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197045. Licensed CC0.

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