# CIRCANNUAL RHYTHMS, BEHAVIOR AND REPRODUCTION

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA BERKELEY · 1994 · $243,840

## Abstract

The overall goal is to specify the neuroendocrine bases for mammalian
circannual rhythms (CARs) in behavior.  All experiments will be conducted
on the golden-mantled ground squirrel (Spermophilus lateralis).  Aims
include: (1) assessing the role of the pineal gland in photic entrainment
of CARs; (2) elaborating the ways in which light and melatonin entrain
CARs; (3) characterizing the phase response curve of CARs to melatonin and
estradiol; (4) determining neural sites at which melatonin and estradiol
phase-shift CARs; (5) localizing circannual pacemakers in the brain; (6)
assessing sex differences in circannual organization; (7) evaluating the
role of the suprachiasmatic nuclei in temporal organization of the
hibernation CAR and (8) establishing whether endogenous gonadal hormones
prevent torpor and signal the end of the hibernation season.
     The biological origin of human annual rhythms, including seasonal
affective dysfunctions, is generally accepted.  The study of CARs in
animals remains the major source of information on the subject and holds
the best prospect of understanding and manipulating human CARs.

## Key facts

- **NIH application ID:** 2197123
- **Project number:** 5R01HD014595-15
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **SAM.gov UEI:** GS3YEVSS12N6
- **Principal Investigator:** IRVING ZUCKER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $243,840
- **Award type:** 5
- **Project period:** 1980-07-01 → 1996-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197123

## Citation

> US National Institutes of Health, RePORTER application 2197123, CIRCANNUAL RHYTHMS, BEHAVIOR AND REPRODUCTION (5R01HD014595-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197123. Licensed CC0.

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