# LIPID CLEARING IN THE PARENTERALLY FED PRETERM INFANT

> **NIH NIH R01** · GEORGETOWN UNIVERSITY · 1994 · $148,002

## Abstract

The aim of this project is to examine the lipid clearing mechanism, the
interaction between the enzymes and cofactors (apolipoproteins) regulating
this process and the relationship between lipase(s) levels, exogenous
(infused) lipid, heparin and endogenously synthesized triglycerides, (very
low density lipoproteins VLDL) and cholesterol (lipoprotein-X).  These
studies will be carried out in premature, parenterally fed infants and in
newborn animals, where not feasable in humans.  Answers to the following
questions will be sought:

1. What is the effect of lipid infusion on endothelial and tissue lipase
levels (lipoprotein lipase-LPL, and hepatic lipase-HL)?  2. What is the
effect of the type of lipid infused?  3. What is the effect of lipid
infusion on the composition of aerum lipids?  4. What is the relationship
between lipid infusion, the appearance of Lipoprotein-X (LP-X) and the
activity of lecithin cholesterol acyl transferase (LCAT) in the circulation
of very low birth weight (VLBW) infants?  5. What is the role of hepatic
lipase in the process of lipid clearing in VLBW infants?  These questions
will be answered by studies of the endothelial and tissue lipases in
newborn animals maintained on regimens similar to the ones employed in the
management of parenterally fed preterm infants and by studies of the
heparin releasable endothelial lipases:  lipoprotein lipase (LPL) and
hepatic lipase (HL), quantitated in serum as post heparin lipolytic
activity - PHLA, in infants maintained on total parenteral nutrition in the
intensive care nursery.  Since VLBW infants are maintained exclusively on
parenteral nutrition and receive lipid infusion for long periods, a better
understanding of all aspects of the lipid clearing mechanism is necessary
for the optimal management of these very premature infants.  These studies
are also leading to development of rapid and highly accurate non-invasive
tests of the lipid clearing ability of preterm infants.

## Key facts

- **NIH application ID:** 2197232
- **Project number:** 5R01HD015631-11
- **Recipient organization:** GEORGETOWN UNIVERSITY
- **SAM.gov UEI:** TF2CMKY1HMX9
- **Principal Investigator:** MARGIT HAMOSH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $148,002
- **Award type:** 5
- **Project period:** 1982-07-01 → 1996-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197232

## Citation

> US National Institutes of Health, RePORTER application 2197232, LIPID CLEARING IN THE PARENTERALLY FED PRETERM INFANT (5R01HD015631-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197232. Licensed CC0.

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