# STEROID HORMONES AND FETAL DEVELOPMENT

> **NIH NIH R01** · OREGON HEALTH & SCIENCE UNIVERSITY · 1993 · $154,303

## Abstract

The purpose of this application is to generate new information
about the organizing actions of androgen at the cellular level on
the brain of two long gestation mammals, the guinea pig and the
rhesus monkey.

Based on preliminary data, experiments are proposed which will
carefully plot changes in the ontogeny of cytosolic androgen
receptors (ARc) in the cortex and hypothalamus of these species at
critical times in fetal development and relate these changes to the
effects of androgen on sexual responsiveness and the capacity of
males to release gonadotropins in a cyclic manner.  Attempts will
be made to systematically evaluate the technique for quantifying
nuclear androgen receptors (ARn) since they can not be measured in
fetal tissues by conventional means.  The actions of tissue
proteases on ARn destruction will be studied as well as possible
localization within the nuclear matrix.  Studies are proposed in
which the role of brain aromatization in sexual differentiation
will be ascertained by the use of aromatase inhibitors during
pregnancy.  In addition molecular probes have been obtained to
study the ontogeny of mRNA for aromatase P-450 in the rhesus monkey
fetus.  Likewise, the capacity of exogenous testosterone to
androgenize the cyclic centers that control gonadotropin release
in the fetal guinea pig will be evaluated.  These studies will
provide new information on cellular events that mediate hormonal
control of brain development.

## Key facts

- **NIH application ID:** 2197260
- **Project number:** 5R01HD016022-12
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **SAM.gov UEI:** NPSNT86JKN51
- **Principal Investigator:** JOHN A RESKO
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $154,303
- **Award type:** 5
- **Project period:** 1981-05-01 → 1995-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197260

## Citation

> US National Institutes of Health, RePORTER application 2197260, STEROID HORMONES AND FETAL DEVELOPMENT (5R01HD016022-12). Retrieved via MORVS 2026-10-26 from https://api.morvs.ai/grant/nih/2197260. Licensed CC0.

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