# STUDIES ON REPRODUCTIVE PHYSIOLOGY IN THE MACAQUE

> **NIH NIH R37** · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 1994 · $324,328

## Abstract

This is the continuation of a research program of long standing, designed
to elucidate the neuroendocrine control systems which govern reproductive
processes in the rhesus monkey, a representative primate.  Much of what is
learned using this experimental model has been and continues to be
applicable to the understanding of human reproductive physiology.  During
the next project period the functioning of the hypothalamic LHRH pulse
generator will be studied in unrestrained females throughout the normal
menstrual cycle, pregnancy, lactation and the advent of puberty.  The
influence of mild pertubations in the environment will also be
investigated.  Pulse generator activity will be assessed using
electrophyciological techniques couples with radiotelemetry permitting
continuous monitoring of this control system in freely behaving animals.

In addition, the ongoing study of the influence of various ovarian factors,
other than estradiol and progesterone, on the hypothalamic LHRH pulse
generator will be continued.

## Key facts

- **NIH application ID:** 2197441
- **Project number:** 5R37HD017438-13
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- **SAM.gov UEI:** ZUFBNVZ587D4
- **Principal Investigator:** ERNST KNOBIL
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $324,328
- **Award type:** 5
- **Project period:** 1982-07-01 → 1996-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197441

## Citation

> US National Institutes of Health, RePORTER application 2197441, STUDIES ON REPRODUCTIVE PHYSIOLOGY IN THE MACAQUE (5R37HD017438-13). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197441. Licensed CC0.

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