# CHROMOSOME 6P AND DEVELOPMENTAL DEFECTS

> **NIH NIH P01** · IMMUNE DISEASE INSTITUTE, INC. · 1994 · $977,579

## Abstract

The proposed studies were designed to provide a molecular analysis of
structure, organization and polymorphisms of genes within the major
histocompatibility complex (MHC) on the short arm of chromosome six (6p)
and particularly as they relate to disease states and the normal immune
response.  Superantigens (bacterial toxins of S. aureus) will be
cocrystallized with MHC class II molecules to define how these toxins bind
to MHC class II molecules.  Gene targeting experiments will be performed
to eliminate genes of factor B and the complement component C4 to define
further the role of MHC class III molecules in the normal immune response.
findings from studies of polymorphisms of MHC molecules will be applied to
disease associations, particularly to defining the MHC association of
common variable immunodeficiency (CVID).  Modern tools of molecular
genetics, protein biosynthesis and protein chemistry will be applied to
the study of patients, their families and normal families with informative
markers on 6p.  The overall objective of this project is an understanding
of diseases associated with the MHC and the finding of predictive
independent markers for these disorders.  Thus, more effective and
comprehensive diagnosis, genetic counselling and treatment strategies
might result.

## Key facts

- **NIH application ID:** 2197454
- **Project number:** 2P01HD017461-11
- **Recipient organization:** IMMUNE DISEASE INSTITUTE, INC.
- **Principal Investigator:** FRED S. ROSEN
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $977,579
- **Award type:** 2
- **Project period:** 1983-04-01 → 1999-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197454

## Citation

> US National Institutes of Health, RePORTER application 2197454, CHROMOSOME 6P AND DEVELOPMENTAL DEFECTS (2P01HD017461-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197454. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*