# MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES

> **NIH NIH R01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 1994 · $56,213

## Abstract

Many common diseases, although familial, appear not to follow simple modes
of inheritance.  In some cases the inheritance may be simple, but
nongenetic factors affect the phenotypes, thereby obscuring the genetic
pattern.  For example, environmental factors which affect the phenotype may
aggregate in families, resulting in nongenetic familiality.  Pleiotropic
genes may produce inconsistent effects on multiple phenotypes.  Assortative
mating may produce more offspring resembling their parents than expected
assuming random mating.  Phenotypic expression may require an environmental
stimulus, resulting in reduced penetrance in its absence.  Aging may
promote expression of the phenotype, mimicking reduced genetic transmission
to offspring.  The expression of the same genotype may differ between males
and females.  Unless the analyses of such phenotypes assume models which
include these nongenetic factors, the genetic effect may be undetectable or
falsely inferred.

This application proposes to develop, implement, and apply genetic models
used to detect major genes in the presence of nongenetic factors.  The
implementation will occur in PAP, a Fortran program for likelihood
analysis.  The extensions proposed include regressive models for univariate
and multivariate phenotypes, age of onset curves, and unequal variances
across PAP for other users will be continued.

## Key facts

- **NIH application ID:** 2197458
- **Project number:** 5R01HD017463-11
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **SAM.gov UEI:** LL8GLEVH6MG3
- **Principal Investigator:** SANDRA J HASSTEDT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $56,213
- **Award type:** 5
- **Project period:** 1983-04-01 → 1995-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197458

## Citation

> US National Institutes of Health, RePORTER application 2197458, MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES (5R01HD017463-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197458. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*