# NEUROENDOCRINE REGULATION OF OVARIAN CYCLICITY

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1993 · $236,635

## Abstract

The neuroendocrine regulation of ovarian cyclicity in a seasonally breeding
species is the theme of this project.  Studies will be performed to
identify signals pertinent to photoperiodic, pineal, hypothalamic and
steroidal regulation of pulsatile LH secretion and response to estradiol
negative feedback in the female sheep.  Particularl emphasis will be placed
on the importance of patterning of these signals to generation of
responses.  The patterns of hypothalamic GnRH and pineal melatonin signals
will be of special interest and will be studied using a portable back-pack
infusion system.  Stereotaxically placed knife-cuts in the hypothalamus and
immunocytochemical localization of GnRH in neurons of the sheep brain will
be used to examine the neural processing of photoperiodic and steroidal
signals which regulate pulsatile LH secretion.  Radioimmunoassays will be
used to measure serum LH, FSH, GnRH, melatonin, estradiol and
progesterone.  It is expected that these findings will lead to new insight
concerning ovarian cyclicity and seasonal breeding, an natural process of
reversable fertility.

## Key facts

- **NIH application ID:** 2197635
- **Project number:** 5R01HD018337-10
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** FRED J KARSCH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $236,635
- **Award type:** 5
- **Project period:** 1984-03-01 → 1994-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197635

## Citation

> US National Institutes of Health, RePORTER application 2197635, NEUROENDOCRINE REGULATION OF OVARIAN CYCLICITY (5R01HD018337-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197635. Licensed CC0.

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